Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.

Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR. Lancet. 2017 Oct 10. pii: S0140-6736(17)32346-2.

Regulatory T cells promote myelin regeneration in the central nervous system.
Dombrowski Y, O’Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJ, Fitzgerald DC. Nat Neurosci. 2017 Mar 13. doi: 10.1038/nn.4528.

Mechanical plasticity during oligodendrocyte differentiation and myelination.Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM. Glia. 2017 Sep 21. doi: 10.1002/glia.23206.

Accelerated Remyelination during Inflammatory Demyelination Prevents Axonal Loss and Improves Functional Recovery.
Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, Sagan SA, Xiao L, Teuscher C, von Budingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. eLife. 2016 Sep 27;5. pii: e18246. doi: 10.7554/eLife.18246.

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination.
Redmond SA, Mei F, Eshed-Eisenbach Y, Osso LA, Leshkowitz D, Shen YA, Kay JN, Aurrand-Lions M, Lyons DA, Peles E, Chan JR. Neuron, 2016 Aug 3; 91:824-836.

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.
Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. J Neurosci. 2016 July 27; 36(30): 7925-7935.

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovicic A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ. Neuron. 2016 July 6; 6;91(1):41-55.

Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity.
Etxeberria A, Hokanson KC, Dao DQ, Mayoral SR, Mei F, Redmond SA, Ullian EM, Chan JR. J Neurosci. 2016 June 29; 36(26):6937-48.

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.
Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR. Nat Neurosci. 2016 Jun 13; 19(8):1060-72

The environment rules: spatiotemporal regulation of oligodendrocyte differentiation.
Mayoral SR, Chan JR. Curr Opin Neurobiol. 2016 April 26;39:47-52.

Remodeling myelination: implications for mechanisms of neural plasticity.
Chang KJ, Redmond SA, Chan JR. Nat Neurosci. 2016 Jan 27; 19(2):190-197.

Oligodendrocyte precursors migrate along vasculature in the developing nervous system.
Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. Science. 2016 Jan 22; 351(6271):379-84.

Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes.
Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. J Neurosci. 2016 Jan 20; 36(3):806-13

Astrocytes Underlie Neuroinflammatory Memory Impairment.
Osso LA, Chan JR. Cell. 2015 Dec 17; 163(7):1574-6.

The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.
von Büdingen HC, Mei F, Greenfield A, Jahn S, Shen YA, Reid HH, McKemy DD, Chan JR. J Cell Biol. 2015 Sep 7. pii: jcb.201504106

Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent.
Shen YA, Chen Y, Dao DQ, Mayoral SR, Wu L, Meijer D, Ullian EM, Chan JR, Lu QR Nat Commun. 2014 Sep 26;5:4991.

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.
Mei F, Fancy SP, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJ, Green A, Hauser SL, Chan JR. Nat Med. 2014 Jul 6.

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.
Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Nature. 2014 May 8; 509(7499):189-94.

Multiple sclerosis: Prospects and promise.
Hauser SL, Chan JR, Oksenberg JR. Ann Neurol. 2013 Sep; 74(3):317-27.

Stage-specific deletion of olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes.
Mei F, Wang H, Liu S, Niu J, Wang L, He Y, Etxeberria A, Chan JR, Xiao L. J Neurosci. 2013 May 8; 33(19):8454-62.

A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers.
Lee S, Chong SY, Tuck SJ, Corey JM, Chan JR. Nat Protoc. 2013 Apr; 8(4):771-82.

Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration.
Mei F, Christin Chong SY, Chan JR. Neurosci Bull. 2013 Apr; 29(2):177-88.

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.
Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR. Cell. 2013 Jan 17; 152(1-2):248-61.

Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A. Sci Signal. 2012 Sep 25; 5(243):ra69.

A culture system to study oligodendrocyte myelination processes using engineered nanofibers.
Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. Nat Methods. 2012 Sep; 9(9):917-22.
(Image used as the cover for Nature Methods Sept 2012 issue, pictured above on the right)

Revitalizing remyelination–the answer is circulating.
Redmond SA, Chan JR. Neuroscience. Science. 2012 Apr 13; 336(6078):161-2.

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.
Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1299-304.

Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. J Biol Chem. 2012 Jan 6; 287(2):1600-8.

Assessing the role of the cadherin/catenin complex at the Schwann cell-axon interface and in the initiation of myelination.
Lewallen KA, Shen YA, De la Torre AR, Ng BK, Meijer D, Chan JR. J Neurosci. 2011 Feb 23; 31(8):3032-43.

Myelin regeneration: a recapitulation of development?
Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. Annu Rev Neurosci. 2011; 34:21-43.

Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis.
Kim YE, Chen J, Langen R, Chan JR. Nat Protoc. 2010 Aug; 5(8):1396-405.

Tapping into the glial reservoir: cells committed to remaining uncommitted.
Chong SY, Chan JR. J Cell Biol. 2010 Feb 8; 188(3):305-12.

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration.
Kim YE, Chen J, Chan JR, Langen R. Nat Methods. 2010 Jan; 7(1):67-73.

A collaboration conducive to conduction: matching axonal density to oligodendroglial number (Commentary on Kawai et al.).
Hahn AT, Chan JR. Eur J Neurosci. 2009 Dec 3; 30(11):2029.

Modulating myelination: knowing when to say Wnt.
Rosenberg SS, Chan JR. Genes Dev. 2009 Jul 1; 23(13):1487-93.

The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation.
Rosenberg SS, Kelland EE, Tokar E, De la Torre AR, Chan JR. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14662-7.
(Image used as the cover for PNAS September 23, 2008 issue, pictured above on the left)

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.
Yamauchi J, Miyamoto Y, Chan JR, Tanoue A. J Cell Biol. 2008 Apr 21; 181(2):351-65.

Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination.
Rosenberg SS, Powell BL, Chan JR. Cell Mol Life Sci. 2007 Dec; 64(23):3059-68.

Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.
Miyamoto Y, Yamauchi J, Chan JR, Okada A, Tomooka Y, Hisanaga S, Tanoue A. J Cell Sci. 2007 Dec 15; 120(Pt 24):4355-66.

Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination.
Ng BK, Chen L, Mandemakers W, Cosgaya JM, Chan JR. J Neurosci. 2007 Jul 11; 27(28):7597-603.

Myelination: all about Rac ‘n’ roll.
Chan JR. J Cell Biol. 2007 Jun 18; 177(6):953-5.

NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination.
Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S. J Neurosci. 2007 Jan 3; 27(1):220-5.

The polarity protein Par-3 directly interacts with p75NTR to regulate myelination.
Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M. Science. 2006 Nov 3; 314(5800):832-6.

The quest for remyelination: a new role for neurotrophins and their receptors.
Rosenberg SS, Ng BK, Chan JR. Brain Pathol. 2006 Oct; 16(4):288-94.

Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.
Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan JR. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14889-94.

The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration.
Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5198-203.

Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking.
Saxena S, Howe CL, Cosgaya JM, Steiner P, Hirling H, Chan JR, Weis J, Krüttgen A. Mol Cell Neurosci. 2005 Mar; 28(3):571-87.

NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes.
Chan JR, Watkins TA, Cosgaya JM, Zhang C, Chen L, Reichardt LF, Shooter EM, Barres BA. Neuron. 2004 Jul 22; 43(2):183-91.

Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.
Yamauchi J, Chan JR, Shooter EM. Proc Natl Acad Sci U S A. 2004 Jun 8; 101(23):8774-9.

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons.
Wu YJ, Krüttgen A, Möller JC, Shine D, Chan JR, Shooter EM, Cosgaya JM. J Neurosci Res. 2004 Mar 15; 75(6):825-34.

Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture.
Ullian EM, Harris BT, Wu A, Chan JR, Barres BA. Mol Cell Neurosci. 2004 Feb; 25(2):241-51.

Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway.
Yamauchi J, Chan JR, Shooter EM. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14421-6.

The neurotrophin receptor p75NTR as a positive modulator of myelination.
Cosgaya JM, Chan JR, Shooter EM. Science. 2002 Nov 8; 298(5596):1245-8.

Neurotrophins are key mediators of the myelination program in the peripheral nervous system.
Chan JR, Cosgaya JM, Wu YJ, Shooter EM. Proc Natl Acad Sci U S A. 2001 Dec 4; 98(25):14661-8.

Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression.
Chan JR, Rodriguez-Waitkus PM, Ng BK, Liang P, Glaser M. Mol Biol Cell. 2000 Jul; 11(7):2283-95.

Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation.
Chan JR, Phillips LJ, Glaser M. Proc Natl Acad Sci U S A. 1998 Sep 1; 95(18):10459-64.

Measurement of the rate of myelination using a fluorescent analogue of ceramide.
Bilderback TR, Chan JR, Harvey JJ, Glaser M. J Neurosci Res. 1997 Aug 15; 49(4):497-507.